Burkitt Lymphoma PI Burkitt-1

The WHO classification of Burkitt’s lymphoma describes three clinical variants: endemic, sporadic (the predominant type found in non-malarial areas), and immunodeficiency-related. These types are similar in morphology, immunophenotype, and genetic features. The endemic variant is associated with malaria endemicity and EBV is found in almost all cases. The sporadic type occurs mainly throughout the rest of the world (predominantly North America and Europe), with no special climatic or geographical links, and is rarely associated with EBV infection. This sporadic-type Burkitt’s lymphoma accounts for 1–2% of adult lymphomas and 30–40% of childhood non-Hodgkin lymphomas in Europe and North America. The immunodeficiency-related type is seen most often in patients with HIV infection and less than 40% of US and European cases are associated with EBV.

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Conflict of Interest Statement
The authors state they have no financial or other interest in the production of this protocol which is done in the interests of public good and to support the established twinning arrangements between the two New Zealand Paediatric oncology centres and colleagues in the Pacific.